Appetite for Destruction is the second single from their final studio album Ni**az4Life. The music video featured members of N.W.A robbing a bank in a 1920s setting. After they rob the bank, the video returns to color and a modern setting. In the last scene, Eazy-E blows the car up killing the other members thus ending the song with the line, "Number 10 is my appetite to kill".
The song appears as part of the West Coast Classic radio station in the video game Grand Theft Auto V.